GPER is involved in the regulation of the estrogen-metabolizing

GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer

INTRODUCTION: Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer death in women worldwide. A prolonged exposure to estrogens has been considered an important factor driving the initiation and progression of diverse hormone-dependent malignancies, including breast tumor.

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