GPER signalling in both cancer

GPER signalling in both cancerassociated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

Cancer-associated fibroblasts (CAFs) as main players within the tumor microenvironment contribute to the growth, expansion and dissemination of cancer cells. For instance, CAFs generate a dynamic signalling network through the secretion of several factors that stimulate adjacent malignant cells toward tumor progression.

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