Dr. Sergio Abonante Chirurgo Senologo
GPER signalling in both cancerassociated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response
Cancer-associated fibroblasts (CAFs) as main players within the tumor microenvironment contribute to the growth, expansion and dissemination of cancer cells. For instance, CAFs generate a dynamic signalling network through the secretion of several factors that stimulate adjacent malignant cells toward tumor progression.