Receptor Modulates FoxO1

IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells

Introduction: Breast cancer is one of the leading causes of cancer-related deaths in the world (1). Tamoxifen, a selective estrogen receptor modulator (SERM), is a commonly prescribed drug for estrogen
receptor (ER)a-positive patients with breast cancer; however, the therapeutic benefits of this drug are diminished by de novo and acquired resistance.

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