Dr. Sergio Abonante Chirurgo Senologo
GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts
Elevated insulin levels have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes characterized by a poor prognosis. Insulin stimulates the proliferation, migration, and invasiveness of cancer cells through diverse transduction pathways, including estrogen signaling.