GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts Elevated insulin levels have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes characterized by a poor prognosis. Insulin stimulates the proliferation, migration, and invasiveness of cancer cells through diverse transduction pathways, …

Skin-Sparing Mastectomy with Immediate Breast and Nipple Reconstruction: A New Technique of Nipple Reconstruction Mastectomy represents the treatment of choice for approximately one-third of women with breast cancer due to aggressive, extensive, or multicentric tumour growth, contraindications for radiotherapy, or following the patient’s wish. Scarica l’Articolo

Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts Methods and results: We used as a model system SKBR3 breast cancer cells and CAFs that lack the classical ERs. Specific pharmacological inhibitors and gene-silencing procedures were used to show that BPA …