GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer INTRODUCTION: Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer death in women worldwide. A prolonged exposure to estrogens has been considered an important factor driving the initiation and progression of …

IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells Introduction: Breast cancer is one of the leading causes of cancer-related deaths in the world (1). Tamoxifen, a selective estrogen receptor modulator (SERM), is a commonly prescribed drug for estrogenreceptor (ER)a-positive patients with breast cancer; however, the therapeutic benefits of …

Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts Objectives: We aimed to evaluate the potential of atrazine to trigger GPER-mediated signaling in cancer cells and cancer-associated fibroblasts (CAFs). Scarica l’Articolo