GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer INTRODUCTION: Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer death in women worldwide. A prolonged exposure to estrogens has been considered an important factor driving the initiation and progression of …

IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells Introduction: Breast cancer is one of the leading causes of cancer-related deaths in the world (1). Tamoxifen, a selective estrogen receptor modulator (SERM), is a commonly prescribed drug for estrogenreceptor (ER)a-positive patients with breast cancer; however, the therapeutic benefits of …

Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts Objectives: We aimed to evaluate the potential of atrazine to trigger GPER-mediated signaling in cancer cells and cancer-associated fibroblasts (CAFs). Scarica l’Articolo

GPER signalling in both cancerassociated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response Cancer-associated fibroblasts (CAFs) as main players within the tumor microenvironment contribute to the growth, expansion and dissemination of cancer cells. For instance, CAFs generate a dynamic signalling network through the secretion of several factors that …

Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs) Scarica l’Articolo

GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts Elevated insulin levels have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes characterized by a poor prognosis. Insulin stimulates the proliferation, migration, and invasiveness of cancer cells through diverse transduction pathways, …

GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts Elevated insulin levels have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes characterized by a poor prognosis. Insulin stimulates the proliferation, migration, and invasiveness of cancer cells through diverse transduction pathways, …

Skin-Sparing Mastectomy with Immediate Breast and Nipple Reconstruction: A New Technique of Nipple Reconstruction Mastectomy represents the treatment of choice for approximately one-third of women with breast cancer due to aggressive, extensive, or multicentric tumour growth, contraindications for radiotherapy, or following the patient’s wish. Scarica l’Articolo

Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts Methods and results: We used as a model system SKBR3 breast cancer cells and CAFs that lack the classical ERs. Specific pharmacological inhibitors and gene-silencing procedures were used to show that BPA …

G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells METHODS AND RESULTS: Atrazine did not transactivate the endogenous ERα in different cancer cell contexts or chimeric proteins encoding the ERα and ERβ hormone-binding domain in gene reporter assays. Moreover, atrazine …