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28 Gennaio

GPER, IGF-IR and EGFR transduction signalling are involved in stimulatory effects of zinc

GPER, IGF-IR and EGFR transduction signalling are involved in stimulatory effects of zinc in breast cancer cells and cancer-associated fibroblasts Abstract: Zinc (Zn) is an essential trace mineral that contributes to the regulation of several cellular functions, however it may be also implicated in the progression of breast cancer through …

28 Gennaio

A calixpyrrole derivative acts as an antagonist to GPER

A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models INTRODUCTION: Breast cancer is the most frequent malignancy in women, and mortality of affected individuals is mainly caused by the development of metastatic processes (Siegel et al., 2012), whichis driven at least in part …

28 Gennaio

Effects of Atrazine on Estrogen Receptor

Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts Objectives: We aimed to evaluate the potential of atrazine to trigger GPER-mediated signaling in cancer cells and cancer-associated fibroblasts Scarica l’articolo

26 Gennaio

GPER Mediates Activation

GPER Mediates Activation of HIF1a/VEGF Signaling by Estrogens Introduction: Breast cancer is the most frequently diagnosed malignancy in women in the United States and the leading cause of cancerrelated death in women worldwide Scarica l’Articolo

26 Gennaio

GPER, IGF‐IR, and EGFR transduction signaling are involved

GPER, IGF‐IR, and EGFR transduction signaling are involved in stimulatory effects of zinc in breast cancer cells and… Introduction: Zinc (Zn) is the second most abundant heavy metal in human tissues and contributes to the regulation of crucial cellular functions. Scarica l’Articolo

26 Gennaio

Effects of Atrazine on Estrogen Receptor

Effects of Atrazine on Estrogen Receptor α– and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts Scarica l’Articolo

23 Gennaio

Breast Cancer and Venous Disease

Breast Cancer and Venous Disease: A Retrospective Cohort Study Breast cancer (BC) and chronic venous disease (CVD) are in some way related to hormonal effects, and often the clinical manifestations of CVD intersect with the clinical course of BC. This article describes the correlations between these clinical conditions. Scarica l’Articolo

23 Gennaio

miR-221 stimulates breast cancer cells and
cancer-associated fibroblasts

miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling Background: MicroRNA (miRNAs) are non-coding small RNA molecules that regulate gene expression by inhibiting the translation of target mRNAs. Among several dysregulated miRNAs in human cancer, the up-regulation of miR-221 has been associated with …

23 Gennaio

GPER is involved in the regulation of the estrogen-metabolizing

GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer INTRODUCTION: Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer death in women worldwide. A prolonged exposure to estrogens has been considered an important factor driving the initiation and progression of …

23 Gennaio

Receptor Modulates FoxO1

IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells Introduction: Breast cancer is one of the leading causes of cancer-related deaths in the world (1). Tamoxifen, a selective estrogen receptor modulator (SERM), is a commonly prescribed drug for estrogenreceptor (ER)a-positive patients with breast cancer; however, the therapeutic benefits of …